کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2779124 1568134 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass
ترجمه فارسی عنوان
وخامت کورتیکال و تربکولر بای پس معده Roux-en-Y در مدل های ماوس
کلمات کلیدی
RYGB، Roux-en-Y معافیت معده؛ PTH، هورمون پاراتیروئید؛ CTX، C-telopeptide، CTX؛ P1NP، نوع 1 procollagen؛ BMI، شاخص توده بدنی؛ BMD، تراکم معدنی استخوان؛ μCT، توموگرافی کامپیوتری میکروسکوپی؛ Tb BV / TV، تراککال مقدار حجم استخوان؛ Tb.Th، ا ترابکولار
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


• Murine models of RYGB recapitulate patterns of bone loss and turnover previously observed in human clinical studies
• RYGB-operated mice had trabecular and cortical bone deficits and increased bone turnover compared to sham-operated controls
• Future studies can leverage this murine model to investigate mechanisms of bone loss after RYGB

Roux-en-Y gastric bypass (RYGB) is a profoundly effective treatment for severe obesity, but results in significant bone loss in patients. Developing a murine model that recapitulates this skeletal phenotype will provide a robust tool with which to study the physiologic mechanisms of this bone loss. We studied adult male C57BL/6J mice who underwent either RYGB or sham operation. Twelve weeks after surgery, we characterized biochemical bone markers (parathyroid hormone, PTH; C-telopeptide, CTX; and type 1 procollagen, P1NP) and bone microarchitectural parameters as measured by microcomputed tomography. RYGB-treated mice had significant trabecular and cortical bone deficits compared with sham-operated controls. Although adjustment for final body weight eliminated observed cortical differences, the trabecular bone volume fraction remained significantly lower in RYGB mice even after weight adjustment. PTH levels were similar between groups, but RYGB mice had significantly higher indices of bone turnover than sham controls. These data demonstrate that murine models of RYGB recapitulate patterns of bone loss and turnover that have been observed in human clinical studies. Future studies that exploit this murine model will help delineate the alterations in bone metabolism and mechanisms of bone loss after RYGB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 85, April 2016, Pages 23–28
نویسندگان
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