کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2788436 | 1568569 | 2016 | 4 صفحه PDF | دانلود رایگان |
• The role of the Ly49 family of receptors in implantation is investigated.
• Knockdown of Ly49 in mice resulted in aberrant crypt formation.
• Knockdown of Ly49 in mice affected blastocyst implantation.
• Ly49 expressed by non-lymphoid leukocytes is important for implantation.
Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate leukocyte functions particularly Natural Killer (NK) cell functions and are analogous to human killer immunoglobulin-like receptors (KIRs). Histological analyses of gd3.5–4.5 B6.Ly49KD uteri identified hatched but retarded blastocysts with pyknotic nuclei, aberrant endometrial crypt formation and impaired uterine lumen closure accompanied by a lack of primary decidualization These data support peri-implantation roles for leukocytes expressing the Ly49 receptor repertoire and may give insight into KIR-based regulation of human infertility.
Journal: Placenta - Volume 39, March 2016, Pages 147–150