Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals

► Persistent activation of inflammatory response has been related to unsuccessful aging. ► Polymorphisms of inflammatory genes can contribute to changes in aging trajectories. ► Aging trajectories differ among sexes. ► We studied the distribution of RANTES and CCR5 variability in long-lived individuals. ► We found a RANTES genetic determinant in sex differences of aging trajectories.