کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2797619 1155659 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2
چکیده انگلیسی

BackgroundThe polymorphism 385 C/A of FAAH has been associated with overweight and obesity. The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C → A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2.DesignA population of 70 patients with diabetes mellitus type 2 was analyzed. An anthropometric and biochemical nutritional assessment was performed. The statistical analysis was performed for the combined C358A and A358A as a group and wild type C358C as second group.ResultsFifty-five patients (78.7%) had genotype C358C (wild type group) and 15 (21.3%) patients C358A (14 patients, 20.6%) or A358A (1 patient, 0.7%) (mutant group). BMI (38.9 ± 6.4 vs. 39.2 ± 5.7, p < 0.05), weight (96.8 ± 17.6 kg vs. 102.5 ± 16.8 kg, p < 0.05), fat mass (42.1 ± 16.1 kg. vs. 46.9 ± 11.1 kg, p < 0.05), waist circumference (115.9 ± 12.8 cm vs. 121.3 ± 12.8 cm, p < 0.05), insulin (22.5 ± 18.8 mUI/L vs. 33.9 ± 17.1 UI/L, p < 0.05) and TNF-alpha (6.1 ± 3.4 pg/mL vs. 8.4 ± 3.2 pg/mL, p < 0.05) were higher in mutant type group than wild type. Adiponectin levels (33.3 ± 20.8 ng/mL vs. 22.3 ± 10.8 ng/mL, p < 0.05) were higher in wild type group than mutant type group.ConclusionThere is an association of the mutant type group A358C and A358A of FAAH with a worse cardiovascular profile (weight, body mass index, waist circumference, insulin,TNF-alpha and adiponectin levels) than wild type group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 88, Issue 1, April 2010, Pages 76–80
نویسندگان
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