کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2799313 | 1155967 | 2014 | 21 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neural innervation of white adipose tissue and the control of lipolysis Neural innervation of white adipose tissue and the control of lipolysis](/preview/png/2799313.png)
• Principal stimulator of lipolysis in mammals is the sympathetic nervous system (SNS).
• White adipose tissue (WAT) has sensory innervation of spinal origin.
• Alterations in SNS drive affects adipocyte proliferation in addition to lipolysis.
• WAT does not appear to possess parasympathetic innervation.
• Insulin and adenosine inhibit SNS-induced lipolysis.
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS–norepinephrine (NE)-mediated WAT lipolysis is dependent on β-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific preventing generalizations among WAT depots and non-WAT organs. Leptin-triggered SNS-mediated lipolysis is weakly supported, whereas insulin or adenosine inhibition of SNS/NE-mediated lipolysis is strongly supported. In addition to lipolysis control, increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively. WAT sensory nerves are of spinal-origin and sensitive to local leptin and increases in sympathetic drive, the latter implicating lipolysis. Transsynaptic viral tract tracers revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis.
Journal: Frontiers in Neuroendocrinology - Volume 35, Issue 4, October 2014, Pages 473–493