Neural plasticity and stress coping in teleost fishes

Physiological and behavioural responses to environmental change are individually variable traits, which manifest phenotypically and are subject to natural selection as correlated trait-clusters (coping styles, behavioural syndromes, or personality traits). Comparative research has revealed a range of neuroendocrine–behavioural associations which are conserved throughout the vertebrate subphylum. Regulatory mechanisms universally mediate a switch between proactive (e.g. active/aggressive) and reactive (e.g. conservation/withdrawal) behaviour in response to unpredictable and uncontrollable events. Thresholds for switching from active coping to behavioural inhibition are individually variable, and depend on experience and genetic factors. Such factors affect physiological stress responses as well as perception, learning, and memory. Here we review the role of an important contributor to neural processing, the set of biochemical, molecular, and structural processes collectively referred to as neural plasticity. We will concentrate on work in teleost fishes, while also elucidating conserved aspects. In fishes, environmental and physiological control of brain cell proliferation and neurogenesis has received recent attention. This work has revealed that the expression of genes involved in CNS plasticity is affected by heritable variation in stress coping style, and is also differentially affected by short- and long-term stress. Chronic stress experienced by subordinate fish in social hierarchies leads to a marked suppression of brain cell proliferation. Interestingly, typically routine dependent and inflexible behaviour in proactive individuals is also associated with low transcription of neurogenesis related genes. The potential for these findings to illuminate stress-related neurobiological disorders in other vertebrates is also discussed.

► Neural plasticity shapes individual stress responses and behavioural profiles.
► Postembryonic neurogenesis is particularly extensive in teleost fishes.
► Environmental and genetic factors controlling neural plasticity are described.
► Severe and long term stress inhibits neural plasticity in fishes.
► Mild and acute challenges are stimulatory.