کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2800850 | 1156131 | 2011 | 5 صفحه PDF | دانلود رایگان |
Neuropeptides, the most diverse group of signaling molecules, are responsible for regulating a variety of cellular and behavioral processes in all vertebrate and invertebrate animals. The role played by peptide signals in information processing is fundamentally different from that of conventional neurotransmitters. Neuropeptides may act as neurotransmitters or neuromodulators and are released at either synaptic or non-synaptic sites. Peptide signals control developmental processes, drive specific behaviors or contribute to the mechanisms of learning and memory storage. Co-transmission within or across peptide families, and between peptide and non-peptide signaling molecules, is common; this ensures the great versatility of their action. How these tasks are fulfilled when multiple neuropeptides are released has become an important topic for peptide research. Although our knowledge concerning the physiological and behavioral roles of most of the neuropeptides isolated from molluscs is incomplete, this article provides examples to address the complexity of peptide signaling.
Research highlights
► The evolution of peptides their receptors led to an enormous diversity and redundancy.
► The high number of peptides and their receptors provided the basis for the adaptation.
► Convergent and divergent actions ensured state-dependent modulation of the signaling system.
► The combined effect of peptides increases the possibility to fine-tune responses of the cell.
► The future challenge in the neuropeptide research would be the search for a suitable model.
Journal: General and Comparative Endocrinology - Volume 172, Issue 1, 15 May 2011, Pages 10–14