Perspectives on concordant and discordant relations between insulin-like growth factor 1 (IGF1) and growth in fishes

Many physiological processes are modulated by the endocrine system, including growth. Insulin-like growth factor 1 is one of the primary hormones involved in growth regulation in vertebrates, including fishes. Current work on IGF1 in fishes is driven both by a desire to better understand mechanisms of growth as well as to develop a reliable index of growth rate. A review of studies relating IGF1 to growth broadly reveals positive and significant relations between IGF1 and growth; however, relations found in individual studies range from no correlation to highly significant correlations. Potential sources for this variation include both biological and methodological issues and range from differences in how growth is defined (changes in length or weight), the duration of growth assessed (weeks to months) and how growth is calculated (total change, rate, percent change); yet, these methodological concerns cannot account for all the variation found. A further review of the literature reveals a number of physiological conditions and environmental factors that might influence IGF1 level and the subsequent relation of that IGF1 level to growth rate. The term concordance is introduced to categorize factors that influence IGF1 and growth in a similar fashion, such that positive and significant relations between IGF1 and growth are maintained even though the factor stimulates changes in IGF1 level. Conversely, the term discordance is introduced to categorize factors that stimulate changes in the relations between IGF1 and growth, such that IGF1 is not an efficacious index of growth for both pre and post-stimulus fish combined. IGF1 and growth relations generally remain concordant after changes in nutrition (consumption rate or diet). Differences in IGF1 level of juvenile, maturing male and maturing female fish are common and IGF1–growth relations appear discordant between these groups. Acute changes in temperature and salinity induce discordant relations between IGF1 and growth but acclimation to persistent differences in environmental condition generally result in concordant relations. Overall, by discriminating between fish of differing physiological status and discerning and categorizing differences among environments one may effectively use IGF1 as a growth index for fishes.

Research highlights
► A review of relations between IGF1 and growth in fishes was conducted.
► Nutritional changes generally did not affect concordance.
► Temperature and salinity affects were varied.
► Maturation and gender strongly affected concordance.
► Overall, for given set of conditions IGF1 and growth were positively correlated.