کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810069 1158402 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prohibitin in Adipose and Immune Functions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Prohibitin in Adipose and Immune Functions
چکیده انگلیسی

Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence. PHB has cell compartment-specific functions, acting as a scaffolding protein in mitochondria, an adaptor molecule in membrane signaling, and a transcriptional coregulator in the nucleus. However, it remains unclear whether different functions and locations of PHB are interrelated or independent from each other, or if PHB works in a tissue-specific manner. Here, we discuss new findings on the role of PHB in adipose–immune interaction and an unexpected role in sex differences in adipose and immune functions.

TrendsProhibitin (PHB) plays a role in sex differences in adipose and immune functions.PHB overexpression in adipose tissue results in obesity in both male and female mice but only males develop obesity-related metabolic dysregulation, steatohepatitis, and hepatocellular carcinoma (HCC) in a sex-specific manner.Overexpression of a mutant Y114F-PHB promotes obesity, adipose inflammation, and insulin resistance, as well as lymph node tumors in a male sex-specific manner but not steatohepatitis and HCC.Male mice overexpressing Y114F-PHB develop adult-onset type 1 diabetes when fed a high-fat diet instead of tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 27, Issue 8, August 2016, Pages 531–541
نویسندگان
, , , ,