کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2810069 | 1158402 | 2016 | 11 صفحه PDF | دانلود رایگان |
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence. PHB has cell compartment-specific functions, acting as a scaffolding protein in mitochondria, an adaptor molecule in membrane signaling, and a transcriptional coregulator in the nucleus. However, it remains unclear whether different functions and locations of PHB are interrelated or independent from each other, or if PHB works in a tissue-specific manner. Here, we discuss new findings on the role of PHB in adipose–immune interaction and an unexpected role in sex differences in adipose and immune functions.
TrendsProhibitin (PHB) plays a role in sex differences in adipose and immune functions.PHB overexpression in adipose tissue results in obesity in both male and female mice but only males develop obesity-related metabolic dysregulation, steatohepatitis, and hepatocellular carcinoma (HCC) in a sex-specific manner.Overexpression of a mutant Y114F-PHB promotes obesity, adipose inflammation, and insulin resistance, as well as lymph node tumors in a male sex-specific manner but not steatohepatitis and HCC.Male mice overexpressing Y114F-PHB develop adult-onset type 1 diabetes when fed a high-fat diet instead of tumors.
Journal: - Volume 27, Issue 8, August 2016, Pages 531–541