کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2810096 | 1158404 | 2016 | 15 صفحه PDF | دانلود رایگان |
Glucagon-like peptide 1 (GLP-1) exerts many actions that improve glycemic control. GLP-1 stimulates glucose-stimulated insulin secretion and protects β cells, while its extrapancreatic effects include cardioprotection, reduction of hepatic glucose production, and regulation of satiety. Although an appealing antidiabetic drug candidate, the rapid degradation of GLP-1 by dipeptidyl peptidase 4 (DPP-4) means that its therapeutic use is unfeasible, and this prompted the development of two main GLP-1 therapies: long-acting GLP-1 analogs and DPP-4 inhibitors. In this review, we focus on the pancreatic effects exerted by current GLP-1 derivatives used to treat diabetes. Based on the results from in vitro and in vivo studies in humans and animal models, we describe the specific actions of GLP-1 analogs on the synthesis, processing, and secretion of insulin, islet morphology, and β cell proliferation and apoptosis.
TrendsAlthough GLP-1-based drugs have been improved to have long-term effects, there are still issues surrounding their oral administration.GLP-1 analogs stimulate insulin synthesis and secretion and inhibit β cell apoptosis in rodent models.Most preclinical studies show increased β cell proliferation and mass after GLP-1 analog treatment; however, whether these effects are also seen in humans remains unclear.GLP-1 analogs reduce plasma glucagon levels, but this effect might not be exerted by a direct action on α cells.
Journal: - Volume 27, Issue 5, May 2016, Pages 304–318