کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2810540 1158454 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Translation of hemodynamic stress to sterile inflammation in the heart
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Translation of hemodynamic stress to sterile inflammation in the heart
چکیده انگلیسی


• Sterile inflammation plays an important role in the genesis of heart failure.
• Mitochondrial DNA that escapes from autophagy leads to inflammation and heart failure.
• The mitochondrial DNA–TLR9 axis is a promising therapeutic target for treating patients with heart failure.
• The inflammasome provides a possible alternative mechanism for sterile inflammation in the heart.

Recently, growing evidence suggests that cardiac inflammation contributes to progression of heart failure (HF). However, the precise mechanism has been elusive. Autophagy is well-known phenomenon which plays essential roles in the maintenance of cardiomyocyte homeostasis by clearing damaged proteins and organelles, and dysfunction of this system evokes HF. Although emerging roles of mitochondria in inflammasome development are highlighted in immune cells, an involvement in the heart has not been defined until recently. This review discusses recent advances in understanding the complex mechanisms underlying cardiac inflammation: these studies have revealed that a combination of mitochondrial autophagy and innate immune responses to mitochondrial DNA during increased hemodynamic stress contribute to cardiac inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 11, November 2013, Pages 546–553
نویسندگان
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