کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820552 1160857 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
All-or-(N)One – an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
All-or-(N)One – an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci
چکیده انگلیسی


• FAM72 is a novel neuronal protein
• FAM72A-D and SRGAP2A-D paralgous genes are paired neighbors
• Four paralogues in humans but only one vertebra-emerging orthologue

FAM72 is a novel neuronal progenitor cell (NPC) self-renewal supporting protein expressed under physiological conditions at low levels in other tissues. Accumulating data indicate the potential pivotal tumourigenic effects of FAM72. Our in silico human genome-wide analysis (GWA) revealed that the FAM72 gene family consists of four human-specific paralogous members, all of which are located on chromosome (chr) 1. Unique asymmetric FAM72 segmental gene duplications are most likely to have occurred in conjunction with the paired genomic neighbour SRGAP2 (SLIT-ROBO Rho GTPase activating protein), as both genes have four paralogues in humans but only one vertebra-emerging orthologue in all other species. No species with two or three FAM72/SRGAP2 gene pairs could be identified, and the four exclusively human-defining ohnologues, with different mutation patterns in Homo neanderthalensis and Denisova hominin, may remain under epigenetic control through long non-coding (lnc) RNAs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 106, Issue 5, November 2015, Pages 278–285
نویسندگان
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