کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2836871 1164863 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium
ترجمه فارسی عنوان
تصویربرداری چندجمله ای نشان می دهد که قاچاق لیپوزوم ها به ترتیب به میوکارد های ایسکمیک است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
چکیده انگلیسی

IntroductionNanoparticles may serve as a promising means to deliver novel therapeutics to the myocardium following myocardial infarction. We sought to determine whether lipid-based liposomal nanoparticles can be shown through different imaging modalities to specifically target injured myocardium following intravenous injection in an ischemia–reperfusion murine myocardial infarction model.MethodsMice underwent ischemia–reperfusion surgery and then either received tail-vein injection with gadolinium- and fluorescent-labeled liposomes or no injection (control). The hearts were harvested 24 h later and underwent T1 and T2-weighted ex vivo imaging using a 7 Tesla Bruker magnet. The hearts were then sectioned for immunohistochemistry and optical fluorescent imaging.ResultsThe mean size of the liposomes was 100 nm. T1-weighted signal intensity was significantly increased in the ischemic vs. the non-ischemic myocardium for mice that received liposomes compared with control. Optical imaging demonstrated significant fluorescence within the infarct area for the liposome group compared with control (163 ± 31% vs. 13 ± 14%, p = 0.001) and fluorescent microscopy confirmed the presence of liposomes within the ischemic myocardium.ConclusionsLiposomes traffic to the heart and preferentially home to regions of myocardial injury, enabling improved diagnosis of myocardial injury and could serve as a vehicle for drug delivery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Revascularization Medicine - Volume 17, Issue 2, March 2016, Pages 106–112
نویسندگان
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