CCK-8 induces fever-like regulated hyperthermia and symptoms of sickness behavior in mice: A biotelemetric study

► CCK-8 given i.c.v. has been known to cause fever and sickness behavior in rats. ► Biotelemetric study in mice infused with this peptide has now shown similar results. ► Decreases in food intake and body mass support the mediator role of CCK-8 in fever.