Association of kidney stones with atherosclerotic cardiovascular disease among adults in the United States: Considerations by race-ethnicity

• Research demonstrates that kidney stone history increases the risk of future CVD.
• Little research has examined whether race-ethnicity moderates this relationship.
• We observed that non-Hispanic blacks with kidney stones had an increased risk of CVD.

BackgroundThere is a paucity of research examining the relationship between kidney stones and risk of cardiovascular disease while considering individuals of different race-ethnicities.PurposeThe purpose of this study was to examine the association between history of kidney stones and increased odds of atherosclerotic cardiovascular disease (via the Pooled Cohort Equations) across race-ethnicity groups.Methods5571 participants aged 40–79 from the 2007–2012 cycles of the NHANES were used for this study. A history of kidney stones was collected from survey data. Predicted odds of having a 10-year atherosclerotic cardiovascular disease (ASCVD) event was assessed from the Pooled Cohort Equations.ResultsAfter adjustments, having kidney stones was not associated with an increase odds of having an ASCVD event within the next 10-years (OR 1.03; 95% CI: 0.58–1.82, P = 0.91). However, among non-Hispanic blacks, those with kidney stones had a 2.24 increased odds (OR 2.24; 95% CI: 1.08–4.66; P = 0.03) of having an ASCVD event within the next 10-years when compared to non-Hispanic blacks with no history of a kidney stone.ConclusionKidney stones were associated with 10-year risk of a future ASCVD event among non-Hispanic blacks.