کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2893623 | 1172417 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Higher IL-6 levels but not IL6 â174GÂ >Â C or â572GÂ >Â C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Caucasian patients undergoing first-time elective CABG were studied. IL-6 levels were measured pre-, 6 h and 24 h following surgery and genotypes for IL6 gene variants â174G > C and â572G > C were obtained. Clinical data was collected daily until patient discharge. Patient outcome was categorised as with (ICUC, n = 177) and without (NICUC, n = 189) a post-operative complication during the ICU period and with (POC, n = 215) and without (NC, n = 151) a post-operative complication during hospitalisation. IL-6 levels pre- and at 24 h were greater in POC and ICUC than NC and NICUC, respectively. Pre- IL-6 levels independently predicted (for 1 standard deviation increase in log IL-6) POC (OR 1.4, 95% CI 1.1-1.7, p = 0.008) and ICUC (OR 1.3, 95% CI 1.0-1.6, p = 0.02) outcomes. Overall, the IL6-572G > C had an effect over time on IL-6 levels (p = 0.04) and on IL-6 levels in NC (P = 0.008) and NICUC (p = 0.006). However, no associations were found with the IL6 â572G > C or â174G > C variants on IL-6 levels at individual time-points or by outcome group. Thus, in conclusion, elevated pre-operative IL-6 levels, but not IL6 gene variants predict poor patient outcome following CABG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 204, Issue 1, May 2009, Pages 196-201
Journal: Atherosclerosis - Volume 204, Issue 1, May 2009, Pages 196-201
نویسندگان
Julie Sanders, Emma Hawe, David J. Brull, Christina Hubbart, Gordon D.O. Lowe, Ann Rumley, Steve E. Humphries, Hugh E. Montgomery,