کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2927392 1176164 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative analysis of biochemical parameters in diabetic and non-diabetic acute myocardial infarction patients
ترجمه فارسی عنوان
تجزیه و تحلیل تطبیقی پارامترهای بیوشیمیایی در بیماران مبتلا به انفارکتوس حاد قلب دیابتی و غیردیابتی
کلمات کلیدی
دیابت نوع 2؛ انفارکتوس حاد قلب؛ نشانگر قلب؛ استرس اکسیداتیو
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundDiabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in diabetic and non-diabetic acute myocardial infarction (AMI) patients.MethodsThis case–control study was conducted on 450 subjects (70–85 years). Subjects were divided into three groups (Normal, N; Non-diabetic AMI, N-AMI; and Diabetic AMI, D-AMI). Each individual was subjected to a detailed history, clinical examination, and cardiovascular parameters analysis (fasting blood sugar, HbA1c, systolic and diasystolic blood pressure, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), TC/HDL and LDL/HDL ratios). Cardiac markers (Troponin-I, creatine phosphokinase (CPK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), C-reactive protein (CRP) and aspartate aminotransferase (AST)) and oxidative stress markers (superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), catalase (CAT)) were also assessed. All these parameters were compared between diabetic and non-diabetic AMI patients.ResultsD-AMI individuals had high level of TC, TG, LDL, and low level of HDL in comparison to N-AMI individuals. Study suggests that cardiac markers such as Troponin I, CPK, CK-MB, AST, LDH, and CRP levels were significantly increased in patients suffering from myocardial infarction with diabetes mellitus (DM) compared to patients of myocardial infarction without DM. The activity levels of antioxidant SOD and GSH were lower in D-AMI patients than in N-AMI. However, levels of MDA and CAT were higher in D-AMI than in N-AMI controls.ConclusionStudy suggests elevated cardiac markers and reduced antioxidants in D-AMI patients compared to N-AMI patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Indian Heart Journal - Volume 68, Issue 3, May–June 2016, Pages 325–331
نویسندگان
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