کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2953271 1577456 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Limitations of Ejection Fraction for Prediction of Sudden Death Risk in Patients With Coronary Artery Disease : Lessons From the MUSTT Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Limitations of Ejection Fraction for Prediction of Sudden Death Risk in Patients With Coronary Artery Disease : Lessons From the MUSTT Study
چکیده انگلیسی

ObjectivesWe determined the contribution of multiple variables to predict arrhythmic death and total mortality risk in patients with coronary disease and left ventricular dysfunction. We then constructed an algorithm to predict risk of mortality and sudden death.BackgroundMany factors in addition to ejection fraction (EF) influence the prognosis of patients with coronary disease. However, there are few tools to use this information to guide clinical decisions.MethodsWe evaluated the relationship between 25 variables and total mortality and arrhythmic death in 674 patients enrolled in the MUSTT (Multicenter Unsustained Tachycardia Trial) study that did not receive antiarrhythmic therapy. We then constructed risk-stratification algorithms to weight the prognostic impact of each variable on arrhythmic death and total mortality risk.ResultsThe variables having the greatest prognostic impact in multivariable analysis were functional class, history of heart failure, nonsustained ventricular tachycardia not related to bypass surgery, EF, age, left ventricular conduction abnormalities, inducible sustained ventricular tachycardia, enrollment as an inpatient, and atrial fibrillation. The model demonstrates that patients whose only risk factor is EF ≤30% have a predicted 2-year arrhythmic death risk <5%.ConclusionsMultiple variables influence arrhythmic death and total mortality risk. Patients with EF ≤30% but no other risk factor have low predicted mortality risk. Patients with EF >30% and other risk factors may have higher mortality and a higher risk of sudden death than some patients with EF ≤30%. Thus, risk of sudden death in patients with coronary disease depends on multiple variables in addition to EF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 50, Issue 12, 18 September 2007, Pages 1150–1157
نویسندگان
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