کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2954386 | 1577527 | 2005 | 12 صفحه PDF | دانلود رایگان |
ObjectivesThe goal of this study was to characterize the origin of focal atrial tachycardias (AT).BackgroundFocal ATs originate from a small area and spread centrifugally; however, activation at the AT origin has not been characterized.MethodsTwenty patients with AT having failed prior ablation or occurring after atrial fibrillation ablation were studied. After excluding macro–re-entry, AT was mapped using a 20-pole catheter (five radiating spines; diameter 3.5 cm), performing vector mapping to identify the earliest activity followed by high-density mapping at the AT origin. Localized re-entry was considered if >85% of the tachycardia cycle length (CL) was observed within the mapping field and was confirmed by entrainment.ResultsA total of 27 ATs were mapped to the pulmonary vein ostia (n = 5), and left (n = 16) and right atria (n = 6). A localized focus was evidenced at the site of origin in 19 ATs (70%), whereas in 8 (30%), localized re-entry was evidenced by 95.2 ± 4.5% of the tachycardia CL recorded within the mapping field and entrainment showed a post-pacing interval <20 ms longer than tachycardia CL (6 of 6 tested). Localized re-entry had a shorter CL (p = 0.009), slowed conduction at its origin (fractionated potential 115 ± 19 ms vs. 64 ± 22 ms, representing 49 ± 10% and 20 ± 10% of tachycardia CL, respectively; p < 0.0001), and were more often contiguous with regions of electrical silence or conduction abnormalities (88% vs. 32%; p = 0.01). In addition, mapping documented varying degrees of intra-atrial conduction block, preferential conduction (n = 5), and rapid bursts of myocardial activity (n = 1). At 11 ± 7 months, none have had recurrence of AT.ConclusionsHigh-density multielectrode mapping can be used to perform vector mapping to localize complex AT. It provides novel insight into the mechanisms of focal AT, distinguishing focal AT from localized re-entry.
Journal: Journal of the American College of Cardiology - Volume 46, Issue 11, 6 December 2005, Pages 2088–2099