کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2964225 1178677 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclosporine reduction causes decreasing of angiotensin II and transforming growth factor-beta expression in chronic allograft nephropathy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cyclosporine reduction causes decreasing of angiotensin II and transforming growth factor-beta expression in chronic allograft nephropathy
چکیده انگلیسی

SummaryBackgroundHigh cyclosporine (CsA) levels might lead to nephrotoxicity due to increasing angiotensin II (AII) and transforming growth factor-beta (TGF-β) production. We hypothesized that a chronic reduction in CsA levels would decrease local renal AII and TGF-β expression and result in improvement of renal function and renal pathological changes in renal transplant recipients.MethodsWe determined the AII and TGF-β expression by immunohistochemical staining (IHCS) in sequential human renal biopsy specimens in patients with chronic allograft nephropathies (time between biopsies: 15.9 ± 0.8 months) after they had their CsA levels reduced by 50%. Pathological evaluation included percentage expression (%) of interstitial fibrosis and tubular atrophy (FIB), vascular sclerosis (VS), transplant glomerulopathy (TG), and vascular hyalinosis (VH). Serum creatinine (CR, mg/dl) and BUN (mg/dl) levels were also investigated.ResultsRenal pathological score significantly improved with chronic reduction in CsA blood levels (FIB: from 52 to 26%, p < 0.05; VS: from 22 to 5%, p < 0.05; TG: from 40 to 13%, p < 0.05; VH: from 17 to 1.8%, p < 0.05, respectively). Renal function also significantly improved with chronic reduction of CsA blood level (BUN: from 84 ± 14 to 40 ± 3 mg/dl, p < 0.05; CR: from 3.4 ± 0.4 to 2.2 ± 0.1 mg/dl, p < 0.05, respectively). AII and TGF-β IHCS score (0–4) and positive staining area (%) were significantly decreased in patients with chronic reduction in CsA levels.ConclusionThese data indicate that chronic reduction in CsA diminishes production of renal tissue AII and AT1 receptor expression, and results in decreased fibrosis and improvement of renal function in patients with chronic allograft nephropathy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiothoracic-Renal Research - Volume 1, Issue 1, March 2006, Pages 81–88
نویسندگان
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