کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
3001504 1406039 2016 10 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
How gut microbes talk to organs: The role of endocrine and nervous routes
ترجمه فارسی عنوان
چگونه میکروب های روده ای با اندامها صحبت می کنند: نقش مسیرهای اندوکرین و عصبی
کلمات کلیدی
میکروبیولوژیک روده؛ متابولیت ها؛ سیستم ایمنی؛ سیستم عصبی در سیستم عصبی؛ سیستم عصبی مرکزی؛ سلولهای انتروندوکریین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی

BackgroundChanges in gut microbiota composition and activity have been associated with different metabolic disorders, including obesity, diabetes, and cardiometabolic disorders. Recent evidence suggests that different organs are directly under the influence of bacterial metabolites that may directly or indirectly regulate physiological and pathological processes.Scope of reviewWe reviewed seminal as well as recent papers showing that gut microbes influence energy, glucose and lipid homeostasis by controlling different metabolic routes such as endocrine, enteric and central nervous system. These dialogues are discussed in the context of obesity and diabetes but also for brain pathologies and neurodegenerative disorders.Major conclusionsThe recent advances in gut microbiota investigation as well as the discovery of specific metabolites interacting with host cells has led to the identification of novel inter-organ communication during metabolic disturbances. This suggests that gut microbes may be viewed as “novel” future therapeutic partners.This article is part of a special issue on microbiota.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Metabolism - Volume 5, Issue 9, September 2016, Pages 743–752
نویسندگان
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