Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation

AimsA percutaneous left ventricular assist device has been shown to be able to perfuse cardiac and cerebral tissues during cardiac arrest and may be a useful supplement to current methods in resuscitation. We wished to assess device-assisted circulation during cardiac arrest with microspheres injections and continuous end-tidal CO2 monitoring, and used cerebral microdialysis to detect ischaemia in the brain.Methods12 anaesthetised pigs had microdialysis and pressure catheters implanted via craniotomy. The percutaneous assist device was deployed transfemorally. Ventricular fibrillation was induced by angioplasty-balloon occlusion of the left coronary artery. Cerebral microdialysis samples representing 0–20 and 20–40 min of cardiac arrest with assisted circulation were analysed for markers of cerebral injury (glucose, pyruvate, lactate, and glycerol).ResultsMicrodialysis showed no ischaemic changes after 20 min of cardiac arrest (P = NS to Baseline for glucose, glycerol, lactate, pyruvate and lactate/pyruvate ratio) in subjects with maintained end-tidal CO2 values above 1.3 kPa (10 mmHg). After 40 min only lactate showed a significant change compared to Baseline (P < 0.05). Microspheres flow to the brain was 57% and myocardial flow was 72% compared to Baseline after 15 min (P < 0.05). After 45 min flow declined to 22% and 40% of Baseline, respectively (P = NS vs. 15 min).ConclusionsA percutaneous left ventricular assist device may prevent ischaemic cerebral injury during cardiac arrest for a limited time. Cerebral injury and tissue perfusion were indicated by end-tidal CO2.