کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3027202 | 1182951 | 2013 | 4 صفحه PDF | دانلود رایگان |
IntroductionQuercetin is widely distributed in plants and has been reported to have effects of anti-inflammation and anti-thrombosis. In this study, we evaluated the protective effect of quercetin on LPS-induced experimental DIC in rabbits, and tried to clarify its mechanism against DIC.Materials and MethodsLPS-induced DIC model in rabbits was established through continuous infusion of 100 ug · kg- 1 · h- 1 LPS for a period of 6 h. Six groups were divided: quercetin-treated groups (0.5, 1.0, and 2.0 mg · kg- 1 · h- 1, respectively), LPS-control group, heparin-control group (100 IU · kg- 1 · h- 1), and saline-control group. APTT, PT, and plasma FIB level were measured, the plasma levels of ALT, BUN, and TNF-α were detected, and the activity of Protein C and ATIII was recorded.ResultsA continuous injection of LPS induced a gradual impairment of hemostatic parameters, a rise in plasma level of TNF-α, and damage in renal and hepatic function. The intravenous administration of quercetin significantly attenuated the increase of APTT, PT, ALT, BUN, and TNF-α, and the decrease of plasma FIB level and activity of Protein C and ATIII.ConclusionQuercetin may have a protective effect against LPS-induced DIC in rabbits through anti-inflammation and anticoagulation.
Journal: Thrombosis Research - Volume 131, Issue 6, June 2013, Pages e270–e273