کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3032106 | 1184001 | 2015 | 10 صفحه PDF | دانلود رایگان |
IntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.
Journal: Alzheimer's & Dementia: Translational Research & Clinical Interventions - Volume 1, Issue 1, June 2015, Pages 53–62