کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3039611 | 1579676 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Stroke remains a leading cause of severe disability and death in the US.
• TURN score predicts sICH after IV thrombolysis for ischemic stroke.
• TURN is computationally simple compared to existing scores.
• TURN predicts sICH well compared to existing scores.
• We derived a clinically meaningful cutoff for sICH prediction.
ObjectiveWe recently described TURN (Thrombolysis risk Using mRS and NIHSS), a computationally simple tool for predicting symptomatic intracerebral hemorrhage (sICH) after IV thrombolysis (rt-PA). Our objective was to compare TURN to existing scores for predicting sICH.MethodsOur internal dataset consisted of 210 ischemic stroke patients receiving IV rt-PA from January 2009 until July 2013 at Yale New Haven Hospital. Our external dataset included 303 patients who received IV rt-PA during the NINDS rt-PA trial. Predictive ability and goodness of fit were quantified by odds ratios (OR) and areas under the receiver operating characteristic curve (AUROC), and compared using unequal variance two-sample t-tests.ResultsTURN predicted sICH with a higher OR than ASTRAL in the internal dataset (2.72 versus 1.10, P = 0.05). We found no other significant differences in OR or AUROC between TURN and other scores in both datasets.ConclusionDespite its computational simplicity, TURN predicts sICH with accuracy comparable to existing scores.
Journal: Clinical Neurology and Neurosurgery - Volume 146, July 2016, Pages 71–75