Very high frequency oscillations (over 1000 Hz) in human epilepsy

ObjectiveHigh frequency oscillations (HFO) of 100–500 Hz have been reported in epileptic human brain. However, the questions of how fast these oscillations can reach, and which frequency range is clinically important remain unanswered. We recorded interictal and ictal very high frequency oscillations (VHFO) of 1000–2500 Hz by subdural electrodes using 10 kHz sampling rate. We describe the characteristics of VHFO, and discuss their underlying mechanism and clinical significance.MethodsFive patients with neocortical epilepsy were studied. All patients underwent intracranial EEG monitoring with subdural electrodes. EEG recording with sampling rate of 10 kHz was conducted. Histopathology revealed malformation of cortical development in all cases.ResultsIn four of five patients, very high frequency activities of 1000–2500 Hz were detected in highly localized cortical regions (one to four electrodes in individual patient). We named these activities “very high frequency oscillations (VHFO)”. Interictally, VHFO appeared intermittently, and were interrupted by spikes. Sustained VHFO without spikes appeared around the start of seizures.ConclusionsBoth interictal and ictal VHFO can be recorded by subdural electrodes. Compared to HFO previously reported, VHFO have much higher frequency, more restricted distribution, smaller amplitude, and different timing of onset.SignificanceRecording of VHFO may be useful for identifying the epileptogenic zone.