Cognitive and neurodevelopmental effects of antiepileptic drugs

This article primarily represents the contributions of two young investigators to the understanding of the neuropsychological consequences of epilepsy and its treatment. The authors have reviewed two key areas of importance: the complex relationship between cognitive dysfunction and epilepsy and the risks of cognitive dysfunction in children as a consequence of in utero exposure to antiepileptic drug treatment. The work of two young investigators is presented and future research needs are outlined.

► Improved methodology into the impact of AED use in pregnancy is enhancing the reliability of information available.
► In utero exposure to VPA is associated with an increase of both cognitive and physical deficits.
► AEDs can induce clinically meaningful adverse cognitive and behavioral side effects in people with epilepsy.
► A better understanding of the character and etiology of cognitive difficulties in people with epilepsy is needed.