کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3051920 1579899 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preoperative evaluation using magnetoencephalography: Experience in 382 epilepsy patients
ترجمه فارسی عنوان
ارزیابی قبل از عمل با استفاده از مغزنگاری مغناطیسی: تجربه در 382 بیمار مبتلا به صرع
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• We describe our database of clinical MEG recordings of 382 epilepsy patients.
• MEG generated a hypothesis about the location of the epileptogenic zone in 68%.
• The generation of a hypothesis by MEG cannot be predicted upfront.
• MEG potentially adds information even in patients with complex etiology.

ObjectiveIdentifying epilepsy patients for whom clinical MEG is likely to be beneficial avoids or optimizes burdensome ancillary investigations. We determined whether it could be predicted upfront if MEG would be able to generate a hypothesis about the location of the epileptogenic zone (EZ), and in which patients MEG fails to do so.MethodsMEG recordings of 382 epilepsy patients with inconclusive findings regarding EZ localization prior to MEG were acquired for preoperative evaluation. MEG reports were categorized for several demographic, clinical and MEG variables. First, demographic and clinical variables were associated with MEG localization ability for upfront prediction. Second, all variables were compared between patients with and without MEG location in order to characterize patients without MEG location.ResultsOur patient group had often complex etiology and did not contain the (by other means) straightforward and well-localized cases, such as those with concordant tumor and EEG location. For our highly-selected patient group, MEG localization ability cannot be predicted upfront, although the odds of a recording with MEG location were significantly higher in the absence of a tumor and in the presence of widespread MRI abnormalities. Compared to the patients with MEG location, patients without MEG location more often had a tumor, widespread EEG abnormalities, non-lateralizing MEG abnormalities, non-concordant MEG/EEG abnormalities and less often widespread MRI abnormalities or epileptiform MEG activity. In a subgroup of 48 patients with known surgery outcome, more patients with concordant MEG and resection area were seizure-free than patients with discordant results.ConclusionsMEG potentially adds information about the location of the EZ even in patients with a complex etiology, and the clinical advice is to not withhold MEG in epilepsy surgery candidates. Providing a hypothesis about the location of the EZ using MEG is difficult in patients with inconclusive EEG and MRI findings, and in the absence of specific epileptiform activity. More refined methods are needed for patients where MEG currently does not contribute to the hypothesis about the location of the EZ.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 124, August 2016, Pages 23–33
نویسندگان
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