کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3052122 | 1186080 | 2014 | 5 صفحه PDF | دانلود رایگان |
• The MTX mini-peptide has shown anticonvulsant activity in the PTZ model of seizure.
• MTX has long-term efficacy in inhibiting/suppressing ictal- and interictal-like activities.
• MTX's protective effects were concentration- and time-dependent.
• An enzymatic treatment of MTX is accompanied by a decrease in the frequency pattern EDs.
SummaryThe present study provides evidence for anti-ictogenic activity of the mystixin 7 (MTX) mini-peptide in the pentylenetetrazole model of seizure. MTX was effective in inhibiting/suppressing ictal- and interictal-like activities over a long period of time (during 60–80 min). The peptide's anti-ictogenic effects were concentration- and time-dependent. An enzymatic treatment of MTX was accompanied by a decrease of the frequency pattern of epileptiform discharges, but their total blockade did not occurred. These findings indicate that the MTX mini-peptide has pronounced anti-ictogenic properties.
Journal: Epilepsy Research - Volume 108, Issue 3, March 2014, Pages 587–591