کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3058109 1580285 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preoperative statin use is not associated with improvement in survival after glioblastoma surgery
ترجمه فارسی عنوان
استفاده از استاتین قبل از عمل با بهبودی در بقا پس از جراحی گلیوبلاستوما همراه نیست
کلمات کلیدی
گلیوبلاستوما؛ استاتین ها؛ عمل جراحي؛ بقا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• The use of perioperative statins is not associated with improvement in progression free survival in glioblastoma multiforme patients.
• Mortality was similar between both groups of patients before and after propensity score matching.
• Age and dexamethasone use were independent prognostic factors of survival.

Cohort studies have suggested that the use of statins is associated with decreased risk of glioma formation and mortality. Here, a cohort of patients with glioblastoma multiforme (GBM) was analyzed to further investigate associations between preoperative use of statins and recurrence, and progression free and overall survival. Patients who had surgery for GBM (N = 284) were followed up for a median of 18.1 months. Seventy-eight patients were taking statins preoperatively while the rest were not. Cox proportional hazards models adjusted for several covariates of interest were applied before and after propensity score matching. Compared with statin users, those not taking the lipid-lowering drugs had similar progression free survival before (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.70–1.26; p = 0.68) and after propensity score matching (HR 0.95, 95% CI 0.67–1.35; p = 0.68). Mortality was similar between both groups of patients before (HR 0.94, 95% CI 0.70–1.22; p =  0.73) and after propensity score matching (HR 1.13, 95% CI 0.78–1.64; p = 0.49). Age and dexamethasone use were independent prognostic factors of survival. Contrary to previously published evidence, this study could not find an association between preoperative statin use and longer survival in GBM patients. Due to the small number of patients and retrospective nature of the study, further work is needed to understand the role of perioperative statins in GBM patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 31, September 2016, Pages 176–180
نویسندگان
, , , , , , , , , , , , , , ,