No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population

• Human FCGR polymorphisms associated with Guillain-Barré Syndrome is studied in a single ethnical population.
• FCGR genotypes and allele frequencies were similar for Guillain Barré Syndrome patients and controls.
• None of FCGR genotypes or alleles were associated with either mild or sever clinical presentation of Guillain-Barré Syndrome.

The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.

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