کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074827 1580955 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders
ترجمه فارسی عنوان
کاهش حالت بارگزاری وابسته به بار وابسته به شبکه در سراسر وظایف اجرایی در اختلالات طیف اسکیزوفرنی
کلمات کلیدی
اختلال طیف شیزوفرنی، در سراسر وظایف، شبکه مثبت وظیفه شبکه حالت پیش فرض تصویربرداری رزونانس مغناطیسی عملکردی، تجزیه و تحلیل جزء مستقل
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• SZ patients have reduced load-dependent DMN deactivation compared to controls.
• TPN activation is associated with task performance, whereas DMN deactivation is not.
• There are only moderate associations between the TPN and DMN activation.

BackgroundSchizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined.MethodsIn the current study, we investigated the recruitment of TPN and DMN using independent component analysis in patients with schizophrenia spectrum disorders (n = 29) and healthy controls (n = 21) during two different executive tasks probing planning/problem-solving and spatial working memory.ResultsWe found reduced load-dependent DMN deactivation across tasks in patients compared to controls. Furthermore, we observed only moderate associations between the TPN and DMN activation across groups, implying that the two networks reflect partly independent mechanisms. Additionally, whereas TPN activation was associated with task performance in both tasks, no such associations were found for DMN.ConclusionThese results support a general load-dependent DMN dysfunction in schizophrenia spectrum disorder across two demanding executive tasks that is not merely an epiphenomenon of cognitive dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, 2016, Pages 389–396
نویسندگان
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