کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3078851 1189271 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sarcocystis fayeri in skeletal muscle of horses with neuromuscular disease
ترجمه فارسی عنوان
Sarcocystis fayeri در عضله اسکلتی اسب با بیماری عصبی ـ عضلانی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• Sarcocystis fayeri infection was common in horses with neuromuscular disease.
• Sarcocystosis could be associated with myopathic and neurogenic processes.
• Similar to human sarcocystosis, cardiomyopathy can also occur in horses.
• Assuming Sarcocysts spp. always being an incidental finding might be inaccurate.

Recent reports of Sarcocystis fayeri-induced toxicity in people consuming horse meat warrant investigation on the prevalence and molecular characterization of Sarcocystis spp. infection in horses. Sarcocysts in skeletal muscle of horses have been commonly regarded as an incidental finding. In this study, we investigated the prevalence of sarcocysts in skeletal muscle of horses with neuromuscular disease. Our findings indicated that S. fayeri infection was common in young mature horses with neuromuscular disease and could be associated with myopathic and neurogenic processes. The number of infected muscles and number of sarcocysts per muscle were significantly higher in diseased than in control horses. S. fayeri was predominantly found in low oxidative highly glycolytic myofibers. This pathogen had a high glycolytic metabolism. Common clinical signs of disease included muscle atrophy, weakness with or without apparent muscle pain, gait deficits, and dysphagia in horses with involvement of the tongue and esophagus. Horses with myositis were lethargic, apparently painful, stiff, and reluctant to move. Similar to humans, sarcocystosis and cardiomyopathy can occur in horses. This study did not establish causality but supported a possible association (8.9% of cases) with disease. The assumption of Sarcocysts spp. being an incidental finding in every case might be inaccurate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 26, Issue 1, January 2016, Pages 85–93
نویسندگان
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