کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3104089 1191641 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of platelet-rich plasma in deep second- and third-degree burns
ترجمه فارسی عنوان
استفاده از پلاسما غنی از پلاکت در سوختگی های عمیق درجه دوم و سوم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی


• We investigated the use of PRP for burn treatment in rats.
• PRP improved healing on deep second-degree burns.
• PRP improved healing on deep second-degree burns associated with diabetes mellitus.
• PRP did not improve healing of third-degree burns.

Unfortunately burns are a common occurrence, leading to scarring or death. Platelet-rich plasma (PRP) contains many growth factors that can accelerate wound healing. We analyzed the use of PRP in deep second-degree (dSD), deep second-degree associated with diabetes mellitus (dSDD), and third-degree (TD) burns in rats. Sixty syngeneic rats divided into three groups (dSD, dSDD, and TD) were burned, half receiving topical PRP and half being used as control; 10 additional rats per group were used for PRP preparation. On day 21, the animals were sacrificed and skin biopsies were collected. dSD and dSDD wounds treated with PRP showed faster wound closure, reduction in CD31-, CD68-, CD163-, MPO-, and in TGF-β-positive cells, and an increase in MMP2-positive cells. The neo-epidermis was thinner in the control of both the dSD and dSDD groups and granulation tissue was less reduced in the control of both the dSDD and TD groups. These results indicate that PRP can accelerate the healing process in dSD and dSDD, but not in TD burns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 42, Issue 4, June 2016, Pages 807–814
نویسندگان
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