کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3121271 | 1583371 | 2009 | 6 صفحه PDF | دانلود رایگان |
Background & objectivesReactive oxygen species (ROS) have been implicated in numerous human diseases, including periodontal diseases. Plasma glutathione peroxidase (eGPx) as an important antioxidant, has a protective role against ROS and is an established marker of oxidative stress. The present study evaluated the levels of eGPx in GCF to further probe into the role of oxidants and antioxidants in periodontal disease.Methods60 subjects were divided into three groups consisting of 20 subjects in each group based on gingival index, pocket probing depth, clinical attachment loss and radiological parameters (bone loss): healthy (group 1), gingivitis (group 2) and periodontitis (group 3), whilst, group 3 patients after the treatment constituted group 4. GCF samples were collected from all groups to estimate the levels of eGPx using ELISA.ResultsThe mean eGPx concentration in GCF were observed to be the highest in group 3 i.e., 30.89 ± 4.93 ng/μl and lowest in group 1 i.e., 15.32 ± 3.06 ng/μl. The mean eGPx concentration in group 2 (23.77 ± 2.91 ng/μl) and group 4 (18.92 ± 3.53 ng/μl) fell between the highest and the lowest values.ConclusionThis suggests that eGPx levels in GCF increase proportionally with the severity of periodontal diseases. eGPx can be considered as a marker of oxidative stress in periodontal diseases. However, controlled, longitudinal studies with larger samples have to be carried out to confirm this possibility.
Journal: Archives of Oral Biology - Volume 54, Issue 6, June 2009, Pages 543–548