Effects of Allogenous Periosteal-Derived Cells Transfected With Adenovirus-Mediated BMP-2 on Repairing Defects of the Mandible in Rabbits

Gene-modified tissue-engineered bone grafts have greater osteogenic potential than single tissue-engineered bone and single bioactive glass ceramic graft. Ex vivo Ad-BMP-2 transfer to periosteal-derived cells can increase bone formation in critical-size bone defects. Further studies are needed to determine if modified engineered cells can be developed for safe and effective clinical applications.