کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3163825 1586258 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prediction model to predict critical weight loss in patients with head and neck cancer during (chemo)radiotherapy
ترجمه فارسی عنوان
مدل پیشبینی برای پیش بینی کاهش وزن بحرانی در بیماران مبتلا به سرطان سر و گردن در طی پرتودرمانی شیمیایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


• We developed a practical decision tree for critical weight loss during (C)RT.
• Predictors were RT to the neck, higher RT dose, RT technique and younger age.
• Weight decreased from the first week of radiotherapy.
• Fifty percent of the 910 patients had critical weight loss during (C)RT.

SummaryObjectivesPatients with head and neck cancer (HNC) frequently encounter weight loss with multiple negative outcomes as a consequence. Adequate treatment is best achieved by early identification of patients at risk for critical weight loss. The objective of this study was to detect predictive factors for critical weight loss in patients with HNC receiving (chemo)radiotherapy ((C)RT).Materials and methodsIn this cohort study, 910 patients with HNC were included receiving RT (±surgery/concurrent chemotherapy) with curative intent. Body weight was measured at the start and end of (C)RT. Logistic regression and classification and regression tree (CART) analyses were used to analyse predictive factors for critical weight loss (defined as >5%) during (C)RT. Possible predictors included gender, age, WHO performance status, tumour location, TNM classification, treatment modality, RT technique (three-dimensional conformal RT (3D-RT) vs intensity-modulated RT (IMRT)), total dose on the primary tumour and RT on the elective or macroscopic lymph nodes.ResultsAt the end of (C)RT, mean weight loss was 5.1 ± 4.9%. Fifty percent of patients had critical weight loss during (C)RT. The main predictors for critical weight loss during (C)RT by both logistic and CART analyses were RT on the lymph nodes, higher RT dose on the primary tumour, receiving 3D-RT instead of IMRT, and younger age.ConclusionCritical weight loss during (C)RT was prevalent in half of HNC patients. To predict critical weight loss, a practical prediction tree for adequate nutritional advice was developed, including the risk factors RT to the neck, higher RT dose, 3D-RT, and younger age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 52, January 2016, Pages 91–96
نویسندگان
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