کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3163834 | 1198748 | 2015 | 6 صفحه PDF | دانلود رایگان |
• Five studies with a total of 443 patients were included in this meta-analysis.
• SND achieves similar regional control in cN+ OSCC patients compared with CND.
• SND gets similar disease-specific survival in cN+ OSCC patients compared with CND.
• SND achieves similar overall survival in cN+ OSCC patients compared with CND.
SummaryObjective: Properly management of cervical lymph node metastases is a critical treatment for patients with oral squamous cell carcinoma (OSCC). However there is no consensus on the optimal treatment for oral cancer patients with clinically node-positive (cN+) neck. This study aims to access the feasibility of selective neck dissection in oral cancer patients with cN+ neck. Method: We searched PubMed and EMBASE up to April 2015 to identify the studies which compared selective neck dissection (SND) with comprehensive neck dissection (CND) in OSCC patients with cN+ neck. Data were extracted by two authors. The meta-analysis was conducted with regional recurrence and disease specific death as primary endpoints. Result: Five studies with a total of 443 patients met our inclusion criteria. No significant difference was found regarding regional recurrence, disease specific death or overall death between the SND and CND group. Conclusion: These findings suggest that cN+ OSCC patients treated with SND in conjunction with adjuvant therapy got comparable clinical outcome to CND.
Journal: Oral Oncology - Volume 51, Issue 12, December 2015, Pages 1076–1081