کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3164821 | 1198811 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma](/preview/png/3164821.png)
SummaryBackground: The tumor suppressor homologue p63 is expressed in basal and parabasal layers of intraoral mucosa. Full length transcripts with transactivational domain (TA forms) present with homology to p53 and implicate functions governing cell proliferation, differentiation and apoptosis control. To date studies show an increase of p63 expression in oral dysplasia and additionally high expression levels correlated with poor prognosis for patients with OSCC, whereas a possible link to radiation resistance of tumors has not been investigated yet. In the present study we tested the hypothesis for p63 being a marker of radioresistance and overall survival in OSCC. Methods: p63 Expression was labeled by immunohistochemistry in pre-treatment biopsies collected from 33 patients with OSCC. Quantification of the labeling index (Li) based on the relation of p63 positive cells to overall tumor cell count. Histological examination of the resection specimen allowed categorization of the radiation response. Statistical analyses of the association between Li and radiation response were performed. Survival analysis utilized Kaplan–Meier estimates and additionally a Cox regression model was built for p63 (Li), T stage, N-stage and chemotherapy and presented as hazard ratios. Results: All tumors had enhanced p63 expression. The median Li was 63.1% (range 36–87%). Tumors with a p63 positive cell count >63.1% showed increased resistance to radiation (p = 0.027). Overall survival was higher (p = 0.001) for patients with low Li (
Journal: Oral Oncology - Volume 46, Issue 9, September 2010, Pages 667–671