کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3165719 | 1198847 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity](/preview/png/3165719.png)
SummaryThis study tested the hypothesis that GLUT-1 is a marker of radioresistance in oral squamous cell carcinomas (OSCC). A GLUT-1 labeling index (LI) was determined by immunohistochemistry in 40 pretreatment OSCC biopsies. Radiation responses were categorized by histopathology of the resection specimens. Associations between the LI and radiation response, Kaplan-Meier survival estimates and Cox regression analysis for the variables GLUT-1, T-stage, N-stage and chemotherapy were examined. The median LI was 64.2% (range 14–100%). Tumors with >65% of GLUT-1 + cells were more resistant to radiation (p = 0.023). Overall survival was higher (p = 0.044) for subjects with low LI (
Journal: Oral Oncology - Volume 43, Issue 8, September 2007, Pages 796–803