کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
317309 1432583 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis
ترجمه فارسی عنوان
نقش ژن MTHFR C677T در حساسیت اسکیزوفرنی:متاآنالیز به روز شده
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Systematic review of MTHFR C677T gene polymorphism in the etiology of schizophrenia.
• This is the largest meta-analysis on the basis of number of studies.
• This is the largest meta-analysis on the basis of sample size.
• T allele of the C677T polymorphism showed the highest association with schizophrenia among Africans.

Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate/homocysteine metabolic pathway. C677T polymorphism of MTHFR gene was reported as risk factor for congenital defects, metabolic and neuropsychiatric disorders. Numerous case-control studies investigated C677T polymorphism as risk factor for schizophrenia but results of these studies were contradictory. To draw a conclusion, a meta-analysis of all available case-control studies was performed. PubMed, Google Scholar, Springer Link and Elsevier databases were searched for eligible case-control studies. Pooled odds ratio with 95%CI was used as an association measure and all statistical analyses were performed by Open Meta-Analyst and MIX software. Total 38 studies with 10,069 cases and 13,372 controls were included in the present meta-analysis. Results of meta-analysis showed significant associated between C677T polymorphism and risk of schizophrenia (ORTvsC = 1.18, 95%CI = 1.10–1.27, p =  < 0.001; ORCTvsCC = 1.10, 95%CI = 1.04–1.17, p = <0.001; ORTTvsCC = 1.40, 95%CI = 1.20–1.64, p = <0.001; ORTT+CTvsCC = 1.19, 95%CI = 1.09–1.30, p = <0.001). We also performed subgroup and sensitivity analyses. Subgroup analysis was done according to ethnicity and significant association was found between C677T polymorphism and risk of schizophrenia in all three ethnic populations—African (OR = 2.51; 95%CI = 1.86–3.40; p = <0.001), Asian (OR = 1.21; 95%CI = 1.10–1.33; p = <0.001) and Caucasian (OR = 1.07; 95%CI = 1.01–1.14; p = 0.01). In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Psychiatry - Volume 20, April 2016, Pages 41–51
نویسندگان
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