کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3268482 1208088 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resection of colorectal liver metastases and extra-hepatic disease: a systematic review and proportional meta-analysis of survival outcomes
ترجمه فارسی عنوان
برداشتن متاستاز کبد کولورکتال و بیماری های اضطراب کبدی: یک بررسی سیستماتیک و متاآنالیز متناسب نتایج حاصل از بقا
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundColorectal cancer (CRC) accounts for 9.7% of all cancers with 1.4 million new cases diagnosed each year. 19–31% of CRC patients develop colorectal liver metastases (CRLM), and 23–38% develop extra-hepatic disease (EHD). The aim of this systematic review was to determine overall survival (OS) in patients resected for CRLM and known EHD.MethodsA systematic review was undertaken to identify studies reporting OS after resection for CRLM in the presence of EHD. Proportional meta-analyses and relative risk of death before five years were assessed between patient groups.ResultsA total of 15,144 patients with CRLM (2308 with EHD) from 52 studies were included. Three and 5-year OS were 58% and 26% for lung, 37% and 17% for peritoneum, and 35% and 15% for lymph nodes, respectively. The combined relative risk of death by five years was 1.49 (95% CI = 1.34–1.66) for lung, 1.59 (95% CI = 1.16–2.17) for peritoneal and 1.70 (95% CI = 1.57–1.84) for lymph node EHD, in favour of resection in the absence of EHD.ConclusionThis review supports attempts at R0 resection in selected patients and rejects the notion that EHD is an absolute contraindication to resection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HPB - Volume 18, Issue 3, March 2016, Pages 209–220
نویسندگان
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