کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
326922 542655 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amygdala hyperactivation to angry faces in intermittent explosive disorder
ترجمه فارسی عنوان
فعال سازی بیش از حد آمیگدال برای چهره‌های عصبانی در اختلال انفجاری متناوب
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Amygdala activation to angry (vs. neutral) faces was greater in IED vs. controls.
• Orbitomedial prefrontal (OMPFC) activation did not differ between groups.
• IED participants also showed less connectivity between the amygdala and OMPFC.

BackgroundIndividuals with intermittent explosive disorder (IED) were previously found to exhibit amygdala hyperactivation and relatively reduced orbital medial prefrontal cortex (OMPFC) activation to angry faces while performing an implicit emotion information processing task during functional magnetic resonance imaging (fMRI). This study examines the neural substrates associated with explicit encoding of facial emotions among individuals with IED.MethodTwenty unmedicated IED subjects and twenty healthy, matched comparison subjects (HC) underwent fMRI while viewing blocks of angry, happy, and neutral faces and identifying the emotional valence of each face (positive, negative or neutral). We compared amygdala and OMPFC reactivity to faces between IED and HC subjects. We also examined the relationship between amygdala/OMPFC activation and aggression severity.ResultsCompared to controls, the IED group exhibited greater amygdala response to angry (vs. neutral) facial expressions. In contrast, IED and control groups did not differ in OMPFC activation to angry faces. Across subjects amygdala activation to angry faces was correlated with number of prior aggressive acts.ConclusionsThese findings extend previous evidence of amygdala dysfunction in response to the identification of an ecologically-valid social threat signal (processing angry faces) among individuals with IED, further substantiating a link between amygdala hyperactivity to social signals of direct threat and aggression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 79, August 2016, Pages 34–41
نویسندگان
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