کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3278498 1407393 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-23p19 expression in patients with ulcerative colitis and its relation to disease severity
ترجمه فارسی عنوان
بیان اینترلوکین-23p19 در بیماران مبتلا به کولیت اولسراتیو و ارتباط آن با شدت بیماری
کلمات کلیدی
ژن 23p19 اینترلوکین ؛ بیان اینترلوکین 23R؛ کولیت اولسراتیو
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

SummaryBackgroundThe purpose of this study was to determine whether the mucosal expression of interleukin (IL)-23p19 has a role in the pathogenesis of ulcerative colitis, and to determine its relation to disease severity.MethodsThis study was performed on 50 patients with ulcerative colitis and 10 normal individuals as the controls. They were divided into Group I (27 patients with mild to moderate disease), Group II (23 patients with severe disease), and Group III (10 normal individuals). All patients and the controls were subjected to histopathological study, IL-23p19 immunohistochemical staining, IL-23R expression by flow cytometry, and serum IL-23 by enzyme-linked immunoassay.ResultsThere was a significant increase in IL-23p19 gene expression and IL-23R level in patients with ulcerative colitis, compared to the controls. A significant positive correlation was detected between increased expression of the IL-23p19 gene, IL-23R, high serum IL-23, and the severity of the disease.ConclusionIncreased expression of the IL-23p19 gene has a role in the pathogenesis of ulcerative colitis. Targeted therapy directed against IL-23p19 may be effective in its treatment. Increased expression of the IL-23p19 gene and IL-23R with high serum IL-23 is correlated positively with disease severity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Digestive Medicine - Volume 3, Issue 3, September 2016, Pages 88–94
نویسندگان
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