کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3288550 | 1209518 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cannabinoides endógenos en la enfermedad hepática: muchos dardos para una sola diana
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
Endogenous cannabinoids are ubiquitous lipid-signaling molecules able to partially mimic the actions produced by Î9-tetrahydrocannabinol, the compound responsible for most of the psychological effects of marijuana. Endocannabinoids are derived from arachidonic acid and are involved in many physiological effects. This family of substances includes anandamide (arachidonylethanolamide), 2-arachydonylglycerol, noladin ether and virodhamine. The interaction of these substances with CB1 and CB2 receptors results in most of their biological effects. The endocannabinoid system is involved in the pathogenesis of the cardiovascular dysfunction occurring in advanced liver disease and also plays a role in the pathogenesis of portal hypertension and liver fibrosis. Moreover, this system is also altered in other processes associated with hepatic dysfunction, including encephalopathy, obesity and steatosis. These findings indicate that the endocannabinoid system may open new avenues for the therapeutic regulation of fibrosis and portal hypertension in advanced liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: GastroenterologÃa y HepatologÃa - Volume 33, Issue 4, April 2010, Pages 323-329
Journal: GastroenterologÃa y HepatologÃa - Volume 33, Issue 4, April 2010, Pages 323-329
نویسندگان
Vedrana Reichenbach, Josefa Ros, Wladimiro Jiménez,