کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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330289 | 1433635 | 2009 | 7 صفحه PDF | دانلود رایگان |
ObjectiveTo analyze whether a positive family history of dementia (PFHD) is more common in sporadic CJD (sCJD) than in healthy/population controls and to study associated risk factors.Patients/methodsSix hundred and eighty-five sCJD patients and 659 sex-/age-matched controls were included. A PFHD in parents/grandparents/siblings was evaluated. The PRNP M129V polymorphism and ApoE genotype in sCJD with/without PFHD were determined by PCR.ResultsPFHD was found in 12.1% of sCJD patients and 5.6% of controls (p < 0.001). No significant difference in M129V polymorphism was found between sCJD with and without PFHD. Thirty-six percent of sCJD patients with PFHD, 26% without PFHD and 19% of healthy controls had at least one ApoE4 allele. Compared to controls, ApoE4 allele frequency (p = 0.005) and proportion of ApoE4 allele carriers (p = 0.019) were significantly higher in sCJD with PFHD.InterpretationA higher frequency of the ApoE4 allele in sCJD with a PFHD could be indicative of an additional risk factor in CJD.
Journal: Neurobiology of Aging - Volume 30, Issue 4, April 2009, Pages 615–621