کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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331093 | 1433629 | 2009 | 11 صفحه PDF | دانلود رایگان |
In vivo measurement of cortical thickness is a sensitive representation of pathology in neurodegenerative disorders which primarily target the gray mantle. In this study we used magnetic resonance images to describe the patterns of cortical thinning in 11 frontotemporal dementia (FTD), 38 Alzheimer's disease (AD) and 34 healthy elderly (HE) subjects. AD and FTD displayed significant thinning of the cortical mantle compared to the HE group, but with distinctive distributions. AD subjects had significantly thinner cortex in all lobes whereas FTD compared to HE showed significant differences only in specific regions of frontal and temporal lobes. When compared to AD, the FTD subjects had a trend of thinner cortex in the anterior cingulate region and in selective regions of anterior frontal and temporal regions. In conclusion, the cortical thinning in dementia when compared to HE, is disease specific whereby FTD subjects display a pattern distinct than that seen in Alzheimer's disease.
Journal: Neurobiology of Aging - Volume 30, Issue 10, October 2009, Pages 1626–1636