کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3337831 | 1591056 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fibroblast growth factor-23, vitamin D and mineral metabolism in renal transplant recipients
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کبدشناسی
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چکیده انگلیسی
In CKD patients various disturbances in vitamin D metabolism in addition to their classical effects on mineral bone disorder (MBD), also can have important effects on innate or adaptive immunity through various signaling pathways. Vitamin D deficiency could be a factor for triggering rejection, chronic allograft nephropathy and infections in post-transplant period. Patients with CKD are known to be both 25-hydroxyvitamin D (25OHD3) and 1,25-dihydroxyvitamin D (1,25[OH]2D3) deficient. Several observational studies have shown that treatment of ESRD patients with vitamin D analogues is associated with improved survival. 1,25(OH)2-D3 has long been recognized to have an immune regulatory function besides its role in calcium homeostasis. There is evidence in literature that indicates that 1,25(OH)2-D3 could have an important role in the regulation of immune function. This could have important clinical implications. Transplant physicians and surgeons should understand that vitamin D has a variety of immunological actions which can have important effect on patient and graft survival after transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Indian Journal of Transplantation - Volume 10, Issue 1, JanuaryâMarch 2016, Pages 1-4
Journal: Indian Journal of Transplantation - Volume 10, Issue 1, JanuaryâMarch 2016, Pages 1-4
نویسندگان
Sonia Mehrotra, Raj K. Sharma, Manas R. Patel, Narayan Prasad, Amit Gupta, Dharmendra S. Bhadauria, Anupama Kaul,