کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3341409 1214208 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety and efficacy of oral direct inhibitors of thrombin and factor Xa in antiphospholipid syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Safety and efficacy of oral direct inhibitors of thrombin and factor Xa in antiphospholipid syndrome
چکیده انگلیسی

BackgroundLong-term anticoagulation is recommended in antiphospholipid syndrome with thrombosis in order to prevent recurrences. While the current mainstay relies on vitamin K antagonists, their long-term maintenance may remain challenging.ObjectivesTo report on the safety and the efficacy of oral direct inhibitors of thrombin and factor Xa (ODIs) in antiphospholipid syndrome (APS).MethodsWe performed a descriptive analysis of patients with APS enrolled in a French multicentre observational cohort between January 2012 and March 2014 and receiving ODIs. The main outcomes were the occurrence of a thrombotic recurrence or bleeding events.ResultsTwenty-six patients with APS (primary in 12) received ODIs. Twenty patients had been previously treated with VKA (n = 19), or fondaparinux (n = 1) for a median duration of 3 years. ODIs were introduced as second-line therapy because of INR lability/therapeutic simplification (n = 17), recurrent thrombosis (n = 1), VKA's associated bleeding event (n = 1), and atrial fibrillation (n = 1). Six patients received ODIs as first-line therapy. After a median [IQR] follow-up of 19 [8–29] months, one relapse of arterial thrombosis, two bleeding events (hypermenorrhea and rectal bleeding under rivaroxaban) and one recurrent migraine were reported, leading to discontinuation of therapy in these 4 patients.ConclusionODIs might be an alternative therapeutic option in APS. Prospective studies are warranted to evaluate their safety in this condition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 14, Issue 8, August 2015, Pages 680–685
نویسندگان
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