کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3341423 | 1214209 | 2015 | 9 صفحه PDF | دانلود رایگان |
• Heart involvement in APS is a common feared complication of this syndrome.
• Valve involvement requiring surgery, has a high risk of thrombotic complications.
• Accelerated atherosclerosis increases the risk of thromboembolic stroke in the young.
• Ischaemic heart disease affects the young leading to a higher risk for heart failure.
• Pulmonary hypertension is a fatal complication of the disease.
Antiphospholipid syndrome is a rare autoimmune disease characterized by a high tendency of developing thrombotic events. It is diagnosed in the presence of specific laboratory criteria (positivity for lupus anticoagulant, and the presence of anticardiolipin and aβ2GPI antibodies) and clinical criteria such as thrombosis in any district (arterial or venous) and pregnancy morbidity. Being a multisystem disease, the heart is commonly affected by direct (autoimmune mediated action) or indirect (thrombosis) pathological mechanisms. Heart valve lesions are the most frequent manifestations; however, the haemodynamic significance is quite uncommon but when it occurs it may require surgery that further complicates the picture due to the high risk of thrombosis. Coronary arteries and myocardium are also affected leading to ischaemic heart disease and left ventricular dysfunction. Other findings include chronic thromboembolic pulmonary hypertension and accelerated atherosclerosis. The consequences of heart involvement may be significant in overt disease. The treatment of cardiac complications is challenging and requires an in-depth knowledge of the disease.
Journal: Autoimmunity Reviews - Volume 14, Issue 3, March 2015, Pages 214–222